Tumor budding in tumor tissue among operatively treated patients with lung adenocarcinoma

Background/Aim. The histological phenomenon of tumor budding is being recognized as an important determinant disease progression and poor prognosis in various types carcinoma. We aimed to evaluate the clinicopathological significance adenocarcinoma lung. Methods. study included 114 patients operatively treated for lung a one-year period. Microscopic analysis routine slides was performed establish presence density buds. These results were compared relation gender, age, size, nodal status, pathological stage. Results. budding-positive group 34 (53.1%) men 27 (54%) women. There 30 (46.9%) 23 (46%) women budding-negative group. No statistical significant difference age found between males (64.3 ? 6.59 years) females (63.1 6.53 group, nor (males 63.3 6.02 years; 63.2 6.72 years). Statistically result size with (p < 0.05). stage N1 III pointed Conclusion. With confirmed higher stage, this study, still relatively new diagnostics domain pathology. However, it increasingly receives attention adverse prognostic factor. may help incorporate into existing staging systems addition other factors known be predictors worse outcome.